Potentialy Of Flavonoid Miana (Coleus Atropurpereus) Leaves Estract As Anti Mycobacterium Tuberculosis H37rv Strain And Mdr With Microscopy Observation Drug Susceptibility (Mods)

Abstract

There is high resistance cases for Isoniazid and Rifampin and more famous withMulti-drug resistant tuberculosis (MDR-TB). From data in Makassar, South sulawesishowed 19,2 MDR-TB cases from new TB patient, and more 13,5% resistance cases forfirstline-TB drugs (STR, INH, RIF,and ETH), and >2 resistance for secondline-TBdrugs (OFL,KAN,AMK). Treatment for tuberculosis mostlly not effective because Multidrugresistanttuberculosis (MDR-TB) cases is very high.WHO recomended traditionalmedicine for improvement of healthy in coummunity, preventive and pharmaceuticalpreparation for all diseases. Research in 2013 showed 85,71% that Torajas TB patientin South Sulawesi used traditional medicine such as Miana (Coleus atropurpereus)leaves estract as complement for TB drugs. Our study showed flavonoid component fromqualitative method used sianida (HCl-Mg) from ethanol 96% Miana (Coleusatropurpereus) leaves estract .Qualitative method using Spektrofotometer UV-V showedthe total of flavonoid component from ethanol 96% miana (Coleus atropurpereus) leavesestract is 8,59 mgRE/gram ekstract.. The result showed were at concentrations (10%,20% ,40 % , 60 % ,80 % and 100%) ethanol 96% miana (Coleus atropurpereus) leavesestract were effecttively inhibit Mycobacterium tuberculosis H37RV strain. Were atconcentration (10%, 20% ,40 % dan 60 %) ethanol 96% miana (Coleus atropurpereus)leaves estract were not effecttively inhibit MDR-TB but effecttively were at concentration (80 % and 100%).